ADS Nyanza serves communities living in the ACK Dioceses of Maseno South, Maseno West, Maseno east, Southern Nyanza and Bondo. This covers the administrative counties of Siaya, Kisumu, Homabay, Nyamira, Kisii and Migori.

The region focuses on the following areas.

• Health – Preventive, Promotive and Advocacy.
• Economic Empowerment.
• Food Security, Water and Sanitation and Environmental Conservation.